Blar i forfatter "Sejersted, Ole M"

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    • Impaired left ventricular mechanical and energetic function in mice after cardiomyocyte-specific excision of Serca2 

      Boardman, Neoma Tove; Aronsen, J. M.; Louch, William Edward; Sjaastad, Ivar; Willoch, Frode; Christensen, Geir Arve; Sejersted, Ole M; Aasum, Ellen (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-01-31)
      Sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)2 transports Ca2+ from the cytosol into the sarcoplasmic reticulum of cardiomyocytes and is essential for maintaining myocardial Ca2+ handling and thus the mechanical function of the heart. SERCA2 is a major ATP consumer in excitation-contraction coupling but is regarded to contribute to energetically efficient Ca2+ handling in the cardiomyocyte. ...